IZKF-N10 LAMP1 Lupus Nephritis (341/M3): LAMP1+ neutrophils in lupus nephritis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2024
End date : 30.06.2026
Project details
Scientific Abstract
My preliminary data highlight that neutrophil phenotypes define distinct SLE patients and that LAMP-1 is a strongly dysregulated protein in SLE. I hypothesize that LAMP1 expression defines a distinct activation state of neutrophils associated with a clinical subgroup of SLE patients with more severe kidney involvement. Hence, this project aims to study the functional role of LAMP1 in neutrophils and probe associations of LAMP1 expression and serum levels with clinical features in SLE.
