J113: Impact of the secretome of ATF2-deficient colon cancer cells on mesothelial cells during peritoneal metastasis
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.11.2024
End date : 30.04.2027
Project details
Scientific Abstract
Although peritoneal metastasis (PM) majorly contributes to colon cancer (CC) related deaths, knowledge on its molecular mechanisms and putative markers is limited. CC tumors deficient for the transcription factor ATF2 are associated with PM. Our project aims to unravel the role of ATF2 loss during peritoneal seeding and, in particular, the effects on mesothelial cells executed by the secretome of ATF2-deficient CC cells. Thereby, novel therapeutic approaches for PM in CC might be identified.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Institute of Pathology
Department of Nephropathology
