Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass

Zacharias HU, Hochrein J, Vogl FC, Schley G, Mayer F, Jeleazcov C, Eckardt KU, Willam C, Oefner PJ, Gronwald W (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Journal of Proteome Research American Chemical Society

Book Volume: 14

Pages Range: 2897-905

Journal Issue: 7

DOI: 10.1021/acs.jproteome.5b00219

Abstract

Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass, but early detection of postoperative AKI remains challenging. Protein biomarkers predict AKI excellently in homogeneous cohorts but are less reliable in patients suffering from various comorbidities. We employed nuclear magnetic resonance spectroscopy in a prospective study of 85 adult cardiac surgery patients to identify metabolites prognostic of AKI in plasma specimens collected 24 h after surgery. Postoperative AKI of stages 1-3, as defined by the Acute Kidney Injury Network (AKIN), developed in 33 cases. A random forests classifier trained on the NMR spectra prognosticated AKI across all stages, with an average accuracy of 80 ± 0.9% and an area under the receiver operating characteristic curve of 0.87 ± 0.01. Prognostications were based, on average, on 24 ± 2.8 spectral features. Among the set of discriminative ions and molecules identified were Mg(2+), lactate, and the glucuronide conjugate of propofol. Using creatinine, Mg(2+), and lactate levels to derive an AKIN index score, we found AKIN 1 disease to be largely indistinguishable from AKIN 0, in concordance with the rather mild nature of AKIN 1 disease.

Authors with CRIS profile

Gunnar Schley Department of Medicine 4 – Nephrology and Hypertension Friederike Mayer Department of Anaesthesiology Christian Jeleazcov Medizinische Fakultät Kai-Uwe Eckardt Department of Medicine 4 – Nephrology and Hypertension Carsten Willam Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Universität Regensburg DE Germany (DE)

How to cite

APA:

Zacharias, H.U., Hochrein, J., Vogl, F.C., Schley, G., Mayer, F., Jeleazcov, C.,... Gronwald, W. (2015). Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass. Journal of Proteome Research, 14(7), 2897-905. https://doi.org/10.1021/acs.jproteome.5b00219

MLA:

Zacharias, Helena U., et al. "Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass." Journal of Proteome Research 14.7 (2015): 2897-905.

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