Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis

Niranjan R, Rajavelu P, Ventateshaiah SU, Shukla JS, Zaidi A, Mariswamy SJ, Mattner J, Fortgang L, Kowalczyk M, Balart L, Shukla A, Mishra A (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Clinical Immunology Elsevier

Book Volume: 157

Pages Range: 103-13

Journal Issue: 2

DOI: 10.1016/j.clim.2015.01.007

Abstract

IL-18 is induced in food allergy and EoE is food allergen-induced disease. Therefore, we tested the hypothesis whether IL-18 is involved in food allergen-induced EoE pathogenesis. Accordingly, we examined normal SPT+ and SPT- EoE patient blood and biopsy samples for IL-18, IL-18R?, ICAM and VCAM expression. Herein, we show increased IL-18 level is highly significant in food allergen SPT+ compared to SPT- EoE patients. We also report that IL-18R?+ cells and mRNA levels are induced in the esophageal biopsies of EoE patients and blood IL-18 levels correlate with esophageal eosinophilia (P<0.01). Additionally, we report that the levels of esophageal eosinophil and mast cells correlate with ICAM expression in human EoE. Mechanistically, we show that IL-18 in vitro stimulates iNKT cells and endothelial cells and induce eosinophil active cytokines IL-5 and IL-13. We provide the evidence that IL-18 is critical cytokine involved in activation of iNKT cells and ICAM in promoting human EoE.

Authors with CRIS profile

Jochen Mattner Professur für Medizinische Mikrobiologie und Infektionsimmunologie

Involved external institutions

Cincinnati Children's Hospital Medical Center US United States (USA) (US) Tulane University US United States (USA) (US)

How to cite

APA:

Niranjan, R., Rajavelu, P., Ventateshaiah, S.U., Shukla, J.S., Zaidi, A., Mariswamy, S.J.,... Mishra, A. (2015). Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis. Clinical Immunology, 157(2), 103-13. https://doi.org/10.1016/j.clim.2015.01.007

MLA:

Niranjan, Rituraj, et al. "Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis." Clinical Immunology 157.2 (2015): 103-13.

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