Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology

Andrulis M, Bäuerle T, Goldschmidt H, Delorme S, Landgren O, Schirmacher P, Hillengass J (2014)

Publication Type: Journal article

Publication year: 2014

Journal

European Journal of Radiology Elsevier

Publisher: Elsevier

Book Volume: 83

Pages Range: 970-4

Journal Issue: 6

DOI: 10.1016/j.ejrad.2014.03.005

Abstract

To investigate how plasma cell infiltration patterns detected by MRI match the plasma cell distribution in bone marrow biopsy.We assessed 50 patients with monoclonal plasma cell disorders of all clinical stages. MRI infiltration pattern was compared with matched BM histology from the same anatomic region.MRI revealed a minimal (n=11, 22%), focal (n=5, 10%), diffuse (n=14, 28%) and mixed (n=20, 40%) infiltration pattern. Diffuse MRI pattern was predominant in smoldering myeloma patients whereas the MRI patterns with "focal component" (i.e. focal and mixed) were most common in symptomatic myeloma (p<0.01). In histology an interstitial (n=13, 26%), nodular (n=23, 46%) and packed marrow (n=14, 28%) was found respectively. All three histological types of infiltration were observed in patients with diffuse and mixed MRI patterns. Minimal MRI pattern was found in all MGUS patients and was associated with an interstitial BM infiltration. In two patients with minimal MRI pattern an extensive micro-nodular BM infiltration was found in histology.Infiltration patterns in MRI represent different histological growth patterns of plasma cells, but the MRI resolution is not sufficient to visualize micro-nodular aggregates of plasma cells.

Authors with CRIS profile

Tobias Bäuerle Professur für Multimodale Bildgebung in der präklinischen Forschung

Involved external institutions

Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) DE Germany (DE) National Cancer Institute (NCI) US United States (USA) (US)

How to cite

APA:

Andrulis, M., Bäuerle, T., Goldschmidt, H., Delorme, S., Landgren, O., Schirmacher, P., & Hillengass, J. (2014). Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology. European Journal of Radiology, 83(6), 970-4. https://doi.org/10.1016/j.ejrad.2014.03.005

MLA:

Andrulis, Mindaugas, et al. "Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology." European Journal of Radiology 83.6 (2014): 970-4.

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