Gmeiner P (2001)
Publication Type: Journal article
Publication year: 2001
Publisher: Thieme Publishing / Georg Thieme Verlag
Pages Range: 2281-2288
DOI: 10.1055/s-2001-18445
Treatment of the acceptor-substituted pyrroles 1a-k with neat triethyl orthoformate gives access to the diethoxymethyl (DEM) protected derivatives 2a-k in high yield. Convenient and mild cleavage was achieved by subsequent treatment of the DEM-pyrroles 2a-k with trifluoroacetic acid in acetonitrile and aqueous NaOH at room temperature. DEM protection proved suitable for a variety of regioselective transformations involving directed orthometalation and iodine-magnesium exchange processes. Furthermore, electrophilic halogenations and Pd-catalyzed coupling reactions were also carried out.
APA:
Gmeiner, P. (2001). Diethoxymethyl Protected Pyrroles: Synthesis and Regioselective Transformations. Synthesis-Stuttgart, 2281-2288. https://doi.org/10.1055/s-2001-18445
MLA:
Gmeiner, Peter. "Diethoxymethyl Protected Pyrroles: Synthesis and Regioselective Transformations." Synthesis-Stuttgart (2001): 2281-2288.
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