Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

Samaratunga H, Delahunt B, Egevad L, Srigley JR, Billis A, Bostwick DG, Camparo P, Cheng L, Clouston D, Denham J, Furusato B, Hartmann A, Jufe L, Kench J, Kenwright DN, Kristiansen G, Leite KR, MacLennan GT, Merrimen J, Moch H, Oxley J, Pan CC, Paner G, Ro J, Sesterhenn IA, Shanks J, Thunders M, Tsuzuki T, Wheeler T, Yaxley JW, Varma M (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

DOI: 10.1016/j.pathol.2019.11.001

Abstract

Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.

Authors with CRIS profile

Involved external institutions

Tissupath Australia (AU) Universidade Estadual de Campinas (UNICAMP) / University of Campinas Brazil (BR) Christie NHS Foundation Trust United Kingdom (GB) Baylor College of Medicine United States (USA) (US) Bostwick Laboratories United States (USA) (US) University of Newcastle (UoN) Australia (AU) Royal Prince Alfred Hospital Australia (AU) Indiana University – Purdue University Indianapolis United States (USA) (US) Centre de Pathologie des Hauts-de-France France (FR) Hospital Carlos G Durand Argentina (AR) University of Otago New Zealand (NZ) Queen Elizabeth II Health Sciences Centre Canada (CA) Weill Cornell Medicine United States (USA) (US) North Bristol NHS Trust United Kingdom (GB) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) University of Chicago United States (USA) (US) University Hospital of Wales (UHW) United Kingdom (GB) Nagasaki University Japan (JP) Taipei Veterans General Hospital / 台北榮民總醫院 Taiwan (TW) Universitätsspital Zürich (USZ) Switzerland (CH) Aichi Medical University / 愛知医科大学 Japan (JP) University Hospitals of Cleveland / Case Western Reserve University Hospital United States (USA) (US) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) University of Toronto Canada (CA) University of Queensland Australia (AU) Universitätsklinikum Bonn Germany (DE)

How to cite

APA:

Samaratunga, H., Delahunt, B., Egevad, L., Srigley, J.R., Billis, A., Bostwick, D.G.,... Varma, M. (2019). Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology. https://doi.org/10.1016/j.pathol.2019.11.001

MLA:

Samaratunga, Hemamali, et al. "Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded." Pathology (2019).

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