Schmitt H (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 18
Journal Issue: 1
DOI: 10.1186/s12871-018-0544-2
BACKGROUND: During anaesthesia it is not uncommon to administer epinephrine in patients blocked by non-depolarizing muscle relaxants. However, there are few reports on possible interaction of epinephrine with neuromuscular transmission in humans. CASE PRESENTATION: An otherwise healthy 74-yr-old man underwent transurethral resection of a benign prostatic hyperplasia under total intravenous anaesthesia. Because of repeated drop in heart rate and blood pressure the patient received in total three bolus of epinephrine 5 μg, respectively. Each time this small dose of epinephrine intensified a rocuronium-induced neuromuscular block verified by acceleromygraphy. Further anaesthetic course was uneventful. CONCLUSIONS: In this case reported here small doses of intravenously administered epinephrine markedly prolonged a rocuronium-induced neuromuscular block. Given the widely used co-administration of epinephrine and muscle relaxants possible adrenergic interference with neuromuscular transmission would have implications for daily anaesthetic practice.
APA:
Schmitt, H. (2018). Small doses of epinephrine prolong the recovery from a rocuronium-induced neuromuscular block: a case report. BMC Anesthesiology, 18(1). https://dx.doi.org/10.1186/s12871-018-0544-2
MLA:
Schmitt, Hubert. "Small doses of epinephrine prolong the recovery from a rocuronium-induced neuromuscular block: a case report." BMC Anesthesiology 18.1 (2018).
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