Liposomal doxorubicin in the treatment of AIDS-associated Kaposi's sarcoma: clinical, histological and cell biological evaluation.

Stürzl M, Zietz C, Eisenburg B, Goebel FD, Gillitzer R, Hofschneider PH, Bogner JR (1994)

Publication Status: Published

Publication Type: Journal article

Publication year: 1994

Journal

RES VIROLOGY

Book Volume: 145

Pages Range: 261-9

Journal Issue: 3-4

DOI: 10.1016/s0923-2516(07)80031-8

Abstract

AIDS-associated Kaposi's sarcoma (KS) in eight patients was treated with the systemic application of liposomal doxorubicin (20 mg/m2 per cycle). After six cycles of treatment a significant regression of KS was observed in all patients. Tumour volume was reduced from 556 +/- 635 mm3 before therapy to 42 +/- 134 mm3 after therapy as determined by ultrasonography of selected tumours. Histological examination revealed a reduction of tumour-like structures and the absence of KS spindle cells in involved areas after therapy. In vitro experiments with KS-derived cell cultures, which most likely represent the KS spindle cells, suggested that liposomal doxorubicin may cause regression of KS via two different mechanisms: (i) by highly specific inhibition of KS spindle cell proliferation and (ii) by induction of monocyte chemoattractant protein-1 expression in KS spindle cells, which may result in increased recruitment of phagocytic cells (monocytes/macrophages) into the lesions. A cooperative action of both mechanisms may explain the high efficacy of liposomal doxorubicin in the treatment of AIDS-KS.

Authors with CRIS profile

Michael Stürzl Professur für Molekulare und Experimentelle Chirurgie

Involved external institutions

Ludwig-Maximilians-Universität (LMU) DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry DE Germany (DE) Universitätsklinikum der Ludwig-Maximilians-Universität München DE Germany (DE) Klinikum der Universität München (Großhadern und Innenstadt) DE Germany (DE)

How to cite

APA:

Stürzl, M., Zietz, C., Eisenburg, B., Goebel, F.D., Gillitzer, R., Hofschneider, P.H., & Bogner, J.R. (1994). Liposomal doxorubicin in the treatment of AIDS-associated Kaposi's sarcoma: clinical, histological and cell biological evaluation. RES VIROLOGY , 145(3-4), 261-9. https://doi.org/10.1016/s0923-2516(07)80031-8

MLA:

Stürzl, Michael, et al. "Liposomal doxorubicin in the treatment of AIDS-associated Kaposi's sarcoma: clinical, histological and cell biological evaluation." RES VIROLOGY 145.3-4 (1994): 261-9.

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