Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes

Wang YX, Yang H, Luo H, Hong SW, Gardiner SK, Jeoung JW, Hardin C, Sharpe GP, Nouri-Mahdavi K, Caprioli J, Demirel S, Girkin CA, Liebmann JM, Mardin C, Quigley HA, Scheuerle AF, Fortune B, Chauhan BC, Burgoyne CF (2020)

Publication Type: Journal article

Publication year: 2020

Journal

American Journal of Ophthalmology Elsevier

Book Volume: 217

Pages Range: 91-103

DOI: 10.1016/j.ajo.2020.03.050

Abstract

Purpose: To use optical coherence tomography (OCT) to 3-dimensionally characterize the optic nerve head (ONH) in peripapillary scleral bowing in non-highly myopic healthy eyes. Design: Cross-sectional, multicenter study. Methods: A total of 362 non-highly myopic (+6 diopters [D] > spherical equivalent > −6D) eyes of 362 healthy subjects from 20-90 years old underwent OCT ONH radial B-scan imaging. Bruch's membrane (BM), BM opening (BMO), anterior scleral canal opening (ASCO), and the peripapillary scleral surface were segmented. BMO and ASCO planes were fit, and their centroids, major axes, ovality, areas and offsets were determined. Peripapillary scleral bowing was characterized by 2 parameters: peripapillary scleral slope (ppSS) of 3 anterior peripapillary scleral segments (0-300, 300-700, and 700-1,000 μm from the ASCO centroid); and ASCO depth relative to a peripapillary scleral reference plane (ASCOD-ppScleral). Peripapillary choroidal thickness (ppCT) was calculated relative to the ASCO as the minimum distance between the anterior scleral surface and BM. Results: Both ppSS and ASCOD-ppScleral ranged from slightly inward through profoundly outward in direction. Both parameters increased with age and were independently associated with decreased ppCT. Conclusions: In non-highly myopic healthy eyes, outward peripapillary scleral bowing achieved substantial levels, was markedly increased with age, and was independently associated with decreased peripapillary choroidal thickness. These findings provide a normative foundation for characterizing this anatomy in cases of high myopia and glaucoma and in eyes with optic disc tilt, torsion, and peripapillary atrophy.

Authors with CRIS profile

Christian Mardin Medizinische Fakultät

Additional Organisation(s)

Department of Ophthalmology

Involved external institutions

Wilmer Eye Institute US United States (USA) (US) Legacy Devers Eye Institute US United States (USA) (US) UCLA Stein Eye Institute US United States (USA) (US) Columbia University Irving Medical Center (CUIMC) US United States (USA) (US) Dalhousie University CA Canada (CA) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) University of Alabama at Birmingham (UAB) US United States (USA) (US)

How to cite

APA:

Wang, Y.X., Yang, H., Luo, H., Hong, S.W., Gardiner, S.K., Jeoung, J.W.,... Burgoyne, C.F. (2020). Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes. American Journal of Ophthalmology, 217, 91-103. https://doi.org/10.1016/j.ajo.2020.03.050

MLA:

Wang, Ya Xing, et al. "Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes." American Journal of Ophthalmology 217 (2020): 91-103.

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