VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?

Backert S, Fronzes R, Waksman G (2008)

Publication Type: Journal article

Publication year: 2008

Journal

Trends in Microbiology Elsevier

Book Volume: 16

Pages Range: 409-413

Journal Issue: 9

DOI: 10.1016/j.tim.2008.07.001

Abstract

Many type-IV secretion systems (T4SSs) of plant and human pathogens assemble a pilus used to inject virulence molecules (effectors) into host target cells. The T4SS of Agrobacterium tumefaciens consists of VirB1-VirB11 and VirD4 proteins. Whether targeting of T4SSs to the host requires a T4SS-adhesin that specifically engages host receptors for delivery of effectors has, until recently, remained unclear. Recent data of Agrobacterium and Helicobacter indicate that two classes of T4SS components, VirB2 and VirB5, might function as adhesins that mediate host-cell targeting through binding to specific host receptors. Here, we discuss this important issue and recent progress in the field. © 2008 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Steffen Backert

Involved external institutions

University College London (UCL) GB United Kingdom (GB) Otto-von-Guericke-Universität Magdeburg DE Germany (DE)

How to cite

APA:

Backert, S., Fronzes, R., & Waksman, G. (2008). VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? Trends in Microbiology, 16(9), 409-413. https://doi.org/10.1016/j.tim.2008.07.001

MLA:

Backert, Steffen, Remi Fronzes, and Gabriel Waksman. "VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?" Trends in Microbiology 16.9 (2008): 409-413.

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