Cortactin: An Achilles' heel of the actin cytoskeleton targeted by pathogens
Selbach M, Backert S (2005)
Publication Type: Journal article, Review article
Publication year: 2005
Journal
Book Volume: 13
Pages Range: 181-189
Journal Issue: 4
DOI: 10.1016/j.tim.2005.02.007
Abstract
Cortactin is an actin-binding protein and a central regulator of the actin cytoskeleton. Importantly, cortactin is also a common target exploited by microbes during infection. Its involvement in disease development is exemplified by a variety of pathogenic processes, such as pedestal formation [enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC)], invasion (Shigella, Neisseria, Rickettsia, Chlamydia, Staphylococcus and Cryptosporidium), actin-based motility (Listeria, Shigella and vaccinia virus) and cell scattering (Helicobacter). Recent progress turns our attention to how cortactin function can be regulated by serine and tyrosine phosphorylation. This has an important impact on how pathogens abuse cortactin to modulate the architecture of the host actin cytoskeleton. © 2005 Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Involved external institutions
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
University of Southern Denmark / Syddansk Universitet
Denmark (DK)
Germany (DE)
University of Southern Denmark / Syddansk Universitet
Denmark (DK)
How to cite
APA:
Selbach, M., & Backert, S. (2005). Cortactin: An Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends in Microbiology, 13(4), 181-189. https://doi.org/10.1016/j.tim.2005.02.007
MLA:
Selbach, Matthias, and Steffen Backert. "Cortactin: An Achilles' heel of the actin cytoskeleton targeted by pathogens." Trends in Microbiology 13.4 (2005): 181-189.
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