Subsets of CD1c+ DCs: Dendritic Cell Versus Monocyte Lineage

Heger L, Hofer TP, Bigley V, de Vries IJM, Dalod M, Dudziak D, Ziegler-Heitbrock L (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 11

Article Number: 559166

DOI: 10.3389/fimmu.2020.559166

Abstract

Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining markers CD1c, CD172, and CD301. When using CD1c to define DC2s, a CD14+ and a CD14− subset can be detected. The CD14+ subset shares features with monocytes, and this includes substantially higher expression levels for CD64, CD115, CD163, and S100A8/9. We review the current knowledge of these CD1c+CD14+ cells as compared to the CD1c+CD14− cells with respect to phenotype, function, transcriptomics, and ontogeny. Here, we discuss informative mutations, which suggest that two populations have different developmental requirements. In addition, we cover subsets of CD11c+CD8− DC2s in the mouse, where CLEC12A+ESAMlow cells, as compared to the CLEC12A−ESAMhigh subset, also express higher levels of monocyte-associated markers CD14, CD3, and CD115. Finally, we summarize, for both man and mouse, the data on lower antigen presentation and higher cytokine production in the monocyte-marker expressing DC2 subset, which demonstrate that the DC2 subsets are also functionally distinct.

Authors with CRIS profile

Lukas Heger Department of Dermatology Diana Dudziak Professur für die Biologie Dendritischer Zellen

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung (IZKF)

Related research project(s)

A080: Control of immune responses by inflammasomes in primary dendritic cells Jan. 1, 2020 - Dec. 31, 2022

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Newcastle University GB United Kingdom (GB) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) NL Netherlands (NL) Aix-Marseille University / Aix-Marseille Université FR France (FR) Monocytomics Research DE Germany (DE)

How to cite

APA:

Heger, L., Hofer, T.P., Bigley, V., de Vries, I.J.M., Dalod, M., Dudziak, D., & Ziegler-Heitbrock, L. (2020). Subsets of CD1c+ DCs: Dendritic Cell Versus Monocyte Lineage. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.559166

MLA:

Heger, Lukas, et al. "Subsets of CD1c+ DCs: Dendritic Cell Versus Monocyte Lineage." Frontiers in Immunology 11 (2020).

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