Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients
Picard M, Yonekura S, Slowicka K, Petta I, Rauber C, Routy B, Richard C, Iebba V, Tidjani Alou M, Becharef S, Ly P, Pizzato E, Lehmann C, Amon L, Klein C, Opolon P, Gomperts Boneca I, Scoazec JY, Hollebecque A, Malka D, Ghiringhelli F, Dudziak D, Berx G, Vereecke L, van Loo G, Kroemer G, Zitvogel L, Roberti MP (2020)
Publication Type: Journal article
Publication year: 2020
Journal
DOI: 10.1038/s41418-020-00684-w
Abstract
Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.
Authors with CRIS profile
Christian Lehmann
Department of Dermatology
Lukas Amon
Department of Dermatology
Diana Dudziak
Professur für die Biologie Dendritischer Zellen
Involved external institutions
Stabilité génétique et oncogenèse
France (FR)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Belgium (BE)
Centre Georges François Leclerc (UNICANCER)
France (FR)
Università degli Studi di Trieste
Italy (IT)
Sorbonne Université
France (FR)
Institut Pasteur
France (FR)
Universiteit Gent (UGent) / Ghent University
Belgium (BE)
France (FR)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Belgium (BE)
Centre Georges François Leclerc (UNICANCER)
France (FR)
Università degli Studi di Trieste
Italy (IT)
Sorbonne Université
France (FR)
Institut Pasteur
France (FR)
Universiteit Gent (UGent) / Ghent University
Belgium (BE)
How to cite
APA:
Picard, M., Yonekura, S., Slowicka, K., Petta, I., Rauber, C., Routy, B.,... Roberti, M.P. (2020). Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients. Cell Death and Differentiation. https://doi.org/10.1038/s41418-020-00684-w
MLA:
Picard, Marion, et al. "Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients." Cell Death and Differentiation (2020).
BibTeX: Download