Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers

Groen SS, Sinkeviciute D, Bay-Jensen AC, Thudium CS, Karsdal MA, Thomsen SF, Schett G, Nielsen SH (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Autoimmunity Reviews Elsevier

Book Volume: 20

Article Number: 102760

Journal Issue: 3

DOI: 10.1016/j.autrev.2021.102760

Abstract

Spondyloarthritis (SpA) is an umbrella term describing a family of chronic inflammatory rheumatic diseases. These diseases are characterised by inflammation of the axial skeleton, peripheral joints, and entheseal insertion sites throughout the body which can lead to structural joint damage including formation of axial syndesmophytes and peripheral osteophytes. Genetic evidence, preclinical and clinical studies indicate a clear role of interleukin (IL)- 23 and IL-17 as mediators in SpA pathogenesis. Targeting the IL-23/−17 pathways seems an efficient strategy for treatment of SpA patients, and despite the remaining challenges the pathway holds great promise for further advances and improved therapeutic opportunities. Much research is focusing on serological markers and imaging strategies to correctly diagnose patients in the early stages of SpA. Biomarkers may facilitate personalised medicine tailored to each patient's specific disease to optimise treatment efficacy and to monitor therapeutic response. This narrative review focuses on the IL-17 pathway in SpA-related diseases with emphasis on its role in pathogenesis, current approved IL-17 inhibitors, and the need for biomarkers reflecting core disease pathways for early diagnosis and measurement of disease activity, prognosis, and response to therapy.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Nordic Bioscience A/S DK Denmark (DK) University of Copenhagen DK Denmark (DK)

How to cite

APA:

Groen, S.S., Sinkeviciute, D., Bay-Jensen, A.C., Thudium, C.S., Karsdal, M.A., Thomsen, S.F.,... Nielsen, S.H. (2021). Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers. Autoimmunity Reviews, 20(3). https://doi.org/10.1016/j.autrev.2021.102760

MLA:

Groen, Solveig Skovlund, et al. "Exploring IL-17 in spondyloarthritis for development of novel treatments and biomarkers." Autoimmunity Reviews 20.3 (2021).

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