SAMHD1 … and Viral Ways around It.

Deutschmann J, Gramberg T (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Viruses MDPI

Book Volume: 13

Journal Issue: 3

DOI: 10.3390/v13030395

Abstract

The SAM and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphohydrolase that plays a crucial role for a variety of different cellular functions. Besides balancing intracellular dNTP concentrations, facilitating DNA damage repair, and dampening excessive immune responses, SAMHD1 has been shown to act as a major restriction factor against various virus species. In addition to its well-described activity against retroviruses such as HIV-1, SAMHD1 has been identified to reduce the infectivity of different DNA viruses such as the herpesviruses CMV and EBV, the poxvirus VACV, or the hepadnavirus HBV. While some viruses are efficiently restricted by SAMHD1, others have developed evasion mechanisms that antagonize the antiviral activity of SAMHD1. Within this review, we summarize the different cellular functions of SAMHD1 and highlight the countermeasures viruses have evolved to neutralize the restriction factor SAMHD1.

Authors with CRIS profile

Janina Deutschmann Institute of Clinical and Molecular Virology Thomas Gramberg Institute of Clinical and Molecular Virology

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung (IZKF)

Related research project(s)

A083: The role of SAMHD1 in CMV/ HIV coinfections Jan. 1, 2020 - Dec. 31, 2022

How to cite

APA:

Deutschmann, J., & Gramberg, T. (2021). SAMHD1 … and Viral Ways around It. Viruses, 13(3). https://doi.org/10.3390/v13030395

MLA:

Deutschmann, Janina, and Thomas Gramberg. "SAMHD1 … and Viral Ways around It." Viruses 13.3 (2021).

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