A time-efficient screening tool for activities of daily living functions in Parkinson’s disease dementia

Sulzer P, Liebig L, Csoti I, Grässel E, Wurster I, Berg D, Liepelt-Scarfone I (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Clinical and Experimental Neuropsychology Taylor & Francis (Psychology Press): STM, Behavioural Science and Public Health Titles / Taylor & Francis (Psychology Press)

Book Volume: 42

Pages Range: 867-879

Journal Issue: 8

DOI: 10.1080/13803395.2020.1825634

Abstract

Instruction: In Parkinson’s disease (PD), activities of daily living (ADL) impairments are crucial for diagnosis of dementia (PDD). Performance-based tests are promising tools to discriminate between different levels of cognitive impairment in PD; however, the value of those tests for diagnosis of PDD is only sparsely investigated. Therefore, we evaluated the Erlangen Test of Activities of Daily Living (E-ADL), a time-efficient performance-based ADL test, in PD. Method: In this cross-sectional study, 40 PD patients with normal cognition (PD-NC), 45 patients with mild cognitive impairment (PD-MCI) and 21 patients with PDD were assessed with a comprehensive ADL and cognitive test battery. Results: Interrater reliability (rs =.86) indicated high consistency of the standardized E-ADL scoring system between raters. The E-ADL correlated significantly with other tests of ADL functions (p <.01), highest with an alternative performance-based ADL test (rs = −.52), and lowest with self-ratings and a physician-rated scale. The E-ADL was also associated with cognitive impairment (p <.01), but also with motor impairment. A binary logistic regression model verified that the E-ADL (p =.04) was an independent predictor of PDD, in addition to motor impairment explaining 53.3% of variance. Receiver operating characteristic curve analysis of the E-ADL revealed an area under the curve of 0.78, a specificity of 77%, and a sensitivity of 67% for diagnosis PDD. Conclusions: The standardized, easy, and quick to administer E-ADL showed acceptable levels of reliability, and validity in PD and measures cognitive-driven ADL functions. Therefore, it might be a suitable test to support diagnosis of PDD in the clinical daily routine.

Authors with CRIS profile

Elmar Grässel Department of Psychiatry and Psychotherapy

Involved external institutions

Christian-Albrechts-Universität zu Kiel DE Germany (DE) Hertie-Institut für klinische Hirnforschung DE Germany (DE)

How to cite

APA:

Sulzer, P., Liebig, L., Csoti, I., Grässel, E., Wurster, I., Berg, D., & Liepelt-Scarfone, I. (2020). A time-efficient screening tool for activities of daily living functions in Parkinson’s disease dementia. Journal of Clinical and Experimental Neuropsychology, 42(8), 867-879. https://doi.org/10.1080/13803395.2020.1825634

MLA:

Sulzer, Patricia, et al. "A time-efficient screening tool for activities of daily living functions in Parkinson’s disease dementia." Journal of Clinical and Experimental Neuropsychology 42.8 (2020): 867-879.

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