The genomic architecture of bladder exstrophy epispadias complex

Beaman GM, Cervellione RM, Keene D, Reutter HM, Newman WG (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

Genes Molecular Diversity Preservation International (MDPI)

Book Volume: 12

Article Number: 1149

Journal Issue: 8

DOI: 10.3390/genes12081149

Abstract

The bladder exstrophy–epispadias complex (BEEC) is an abdominal midline malformation comprising a spectrum of congenital genitourinary abnormalities of the abdominal wall, pelvis, urinary tract, genitalia, anus, and spine. The vast majority of BEEC cases are classified as non-syndromic and the etiology of this malformation is still unknown. This review presents the current knowledge on this multifactorial disorder, including phenotypic and anatomical characterization, epidemiology, proposed developmental mechanisms, existing animal models, and implicated genetic and environmental components.

Authors with CRIS profile

Heiko Martin Reutter Professur für Neonatologie

Involved external institutions

Royal Manchester Children's Hospital GB United Kingdom (GB) Manchester University NHS Foundation Trust (MFT) GB United Kingdom (GB)

How to cite

APA:

Beaman, G.M., Cervellione, R.M., Keene, D., Reutter, H.M., & Newman, W.G. (2021). The genomic architecture of bladder exstrophy epispadias complex. Genes, 12(8). https://doi.org/10.3390/genes12081149

MLA:

Beaman, Glenda M., et al. "The genomic architecture of bladder exstrophy epispadias complex." Genes 12.8 (2021).

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