Innate PD-L1 limits T cell mediated adipose tissue inflammation

Schwartz C, Schmidt V, Deinzer A, Hawerkamp HC, Hams E, Bayerlein J, Roeger O, Bailer M, Krautz C, El Gendy A, Elshafei M, Hogan AE, O'Shea D, Fallon PG (2022)

Publication Type: Conference contribution

Publication year: 2022

Journal

European Journal of Immunology Wiley-VCH Verlag

Publisher: WILEY

City/Town: HOBOKEN

Pages Range: 80-80

Conference Proceedings Title: EUROPEAN JOURNAL OF IMMUNOLOGY

Abstract

Obesity has become a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis; however, the initial events that shift the balance from a noninflammatory homeostatic environment toward inflammation leading to obesity are poorly understood. Here, we report a role for the costimulatory molecule programmed death-ligand 1 (PD-L1) in the limitation of diet-induced obesity. Functional ablation of PD-L1 on dendritic cells (DCs) using conditional knockout mice increased weight gain and metabolic syndrome during diet-induced obesity, whereas PD-L1 expression on type 2 innate lymphoid cells (ILC2s), T cells, and macrophages was dispensable for obesity control. Using in vitro cocultures, DCs interacted with T cells and ILC2s via the PD-L1:PD-1 axis to inhibit T helper type 1 proliferation and promote type 2 polarization, respectively. A role for PD-L1 in adipose tissue regulation was also shown in humans, with a positive correlation between PD-L1 expression in visceral fat of people with obesity and elevated body weight. Thus, we define a mechanism of adipose tissue homeostasis controlled by the expression of PD-L1 by DCs, which may be a clinically relevant finding with regard to immune-related adverse events during immune checkpoint inhibitor therapy.

Authors with CRIS profile

Christian Schwartz Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Viviane Schmidt Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Jasmin Bayerlein Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene Christian Krautz Department of Surgery Moustafa Elshafei Department of Surgery

Involved external institutions

St. Vincent's University Hospital (SVUH) IE Ireland (IE) Trinity College Dublin IE Ireland (IE) Maynooth University IE Ireland (IE)

How to cite

APA:

Schwartz, C., Schmidt, V., Deinzer, A., Hawerkamp, H.C., Hams, E., Bayerlein, J.,... Fallon, P.G. (2022). Innate PD-L1 limits T cell mediated adipose tissue inflammation. In EUROPEAN JOURNAL OF IMMUNOLOGY (pp. 80-80). HOBOKEN: WILEY.

MLA:

Schwartz, Christian, et al. "Innate PD-L1 limits T cell mediated adipose tissue inflammation." Proceedings of the EUROPEAN JOURNAL OF IMMUNOLOGY HOBOKEN: WILEY, 2022. 80-80.

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