Periodontitis-Derived Dark-NETs in Severe Covid-19

Vitkov L, Knopf J, Krunić J, Schoen J, Minnich B, Hannig M, Herrmann M, Schauer C (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 13

Article Number: 872695

DOI: 10.3389/fimmu.2022.872695

Abstract

The frequent severe COVID-19 course in patients with periodontitis suggests a link of the aetiopathogenesis of both diseases. The formation of intravascular neutrophil extracellular traps (NETs) is crucial to the pathogenesis of severe COVID-19. Periodontitis is characterised by an increased level of circulating NETs, a propensity for increased NET formation, delayed NET clearance and low-grade endotoxemia (LGE). The latter has an enormous impact on innate immunity and susceptibility to infection with SARS-CoV-2. LPS binds the SARS-CoV-2 spike protein and this complex, which is more active than unbound LPS, precipitates massive NET formation. Thus, circulating NET formation is the common denominator in both COVID-19 and periodontitis and other diseases with low-grade endotoxemia like diabetes, obesity and cardiovascular diseases (CVD) also increase the risk to develop severe COVID-19. Here we discuss the role of propensity for increased NET formation, DNase I deficiency and low-grade endotoxaemia in periodontitis as aggravating factors for the severe course of COVID-19 and possible strategies for the diminution of increased levels of circulating periodontitis-derived NETs in COVID-19 with periodontitis comorbidity.

Authors with CRIS profile

Jasmin Knopf Department of Medicine 3 – Rheumatology and Immunology Janina Schoen Department of Medicine 3 – Rheumatology and Immunology Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology Christine Schauer Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) University of East Sarajevo (UES) / Univerzitet u Istočnom Sarajevu / Универзитет у Источном Сарајеву BA Bosnia And Herzegovina (BA) Universität Salzburg (Paris Lodron Universität Salzburg) AT Austria (AT)

How to cite

APA:

Vitkov, L., Knopf, J., Krunić, J., Schoen, J., Minnich, B., Hannig, M.,... Schauer, C. (2022). Periodontitis-Derived Dark-NETs in Severe Covid-19. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.872695

MLA:

Vitkov, Ljubomir, et al. "Periodontitis-Derived Dark-NETs in Severe Covid-19." Frontiers in Immunology 13 (2022).

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