Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, Mccall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Thorsson V, Bass AJ, Laird PW (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 33

Pages Range: 721-735.e8

Journal Issue: 4

DOI: 10.1016/j.ccell.2018.03.010

Abstract

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1.

Involved external institutions

Eli and Edythe L. Broad Institute of MIT and Harvard United States (USA) (US) Van Andel Institute United States (USA) (US) Vanderbilt University United States (USA) (US) Memorial Sloan Kettering Cancer Center United States (USA) (US) Stanford University United States (USA) (US) University of Calgary Canada (CA) British Columbia Cancer Agency Canada (CA) University of Texas MD Anderson Cancer Center United States (USA) (US) National Cancer Institute (NCI) United States (USA) (US) Case Western Reserve University United States (USA) (US) Mayo Clinic United States (USA) (US) Duke University United States (USA) (US) George Washington University (GWU) United States (USA) (US) University of Alabama at Birmingham (UAB) United States (USA) (US) Dana–Farber Cancer Institute United States (USA) (US) PharmiWeb Solutions United Kingdom (GB)

How to cite

APA:

Liu, Y., Sethi, N.S., Hinoue, T., Schneider, B.G., Cherniack, A.D., Sanchez-Vega, F.,... Laird, P.W. (2018). Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell, 33(4), 721-735.e8. https://doi.org/10.1016/j.ccell.2018.03.010

MLA:

Liu, Yang, et al. "Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas." Cancer Cell 33.4 (2018): 721-735.e8.

BibTeX: Download