Evaluation of multidisciplinary team decisions in neuroendocrine neoplasms: Impact of expert centres
Zandee WT, Merola E, Poczkaj K, de Mestier L, Klümpen HJ, Geboes K, de Herder WW, Munir A (2022)
Publication Type: Journal article
Publication year: 2022
Journal
DOI: 10.1111/ecc.13639
Abstract
Objective: To evaluate the impact of multidisciplinary team (MDT) meetings on the management of patients with neuroendocrine neoplasms (NENs). Methods: All newly referred gastro-entero-pancreatic (GEP)-NEN patients discussed from 1 April to 1 October 2017 in the MDT of seven European expert centres were prospectively included. The impact on patients' management was defined as a change in diagnosis, grade, stage or treatment. Results: A total of 292 patients were included, mainly small intestinal (siNENs) (32%) and pancreatic NENs (28%), with distant metastases in 51%. Patients had received prior surgery in 43% of cases and prior medical treatment in 32%. A significant change occurred in 61% of NENs: 7% changes in diagnosis, 8% in grade and 16% in stage. The MDT recommended a new treatment for 51% of patients, mainly surgery (9%) or somatostatin analogues (20%). A significant change was most frequently observed in patients with Stage IV disease (hazard ratio [HR] 3.6, 95% confidence interval [CI]: 1.9–6.9 vs. Stage I) and G2 NENs (vs. G1, HR 2.1 95% CI: 1.2–3.8). Conclusion: NEN-dedicated MDT discussion in expert centres yields significant management changes in over 60% of patients and thus represents the gold standard for the management of these patients.
Involved external institutions
University of Amsterdam
Netherlands (NL)
University Hospital Ghent
Belgium (BE)
Beaujon Hospital / Hôpital Beaujon
France (FR)
Erasmus University Medical Center (MC)
Netherlands (NL)
Royal Hallamshire Hospital
United Kingdom (GB)
Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM)
Poland (PL)
Netherlands (NL)
University Hospital Ghent
Belgium (BE)
Beaujon Hospital / Hôpital Beaujon
France (FR)
Erasmus University Medical Center (MC)
Netherlands (NL)
Royal Hallamshire Hospital
United Kingdom (GB)
Medical University of Silesia in Katowice / Śląski Uniwersytet Medyczny w Katowicach (SUM)
Poland (PL)
How to cite
APA:
Zandee, W.T., Merola, E., Poczkaj, K., de Mestier, L., Klümpen, H.J., Geboes, K.,... Munir, A. (2022). Evaluation of multidisciplinary team decisions in neuroendocrine neoplasms: Impact of expert centres. European Journal of Cancer Care. https://doi.org/10.1111/ecc.13639
MLA:
Zandee, Wouter T., et al. "Evaluation of multidisciplinary team decisions in neuroendocrine neoplasms: Impact of expert centres." European Journal of Cancer Care (2022).
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