Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey

Yoshida A, Kim M, Kuwana M, Ravichandran N, Makol A, Sen P, Lilleker JB, Agarwal V, Kardes S, Day J, Milchert M, Joshi M, Gheita T, Salim B, Velikova T, Edgar Gracia-Ramos A, Parodis I, Selva O'Callaghan A, Nikiphorou E, Chatterjee T, Tan AL, Nune A, Cavagna L, Saavedra MA, Shinjo SK, Ziade N, Knitza J, Distler O, Chinoy H, Agarwal V, Aggarwal R, Gupta L (2022)

Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1093/rheumatology/keac441

Abstract

Objectives The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs. Methods Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease. Results A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P < 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis. Conclusion Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.

Authors with CRIS profile

Involved external institutions

Nippon Medical School Japan (JP) University of Illinois at Urbana-Champaign United States (USA) (US) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) Mayo Clinic United States (USA) (US) Maulana Azad Medical College (MAMC) India (IN) University of Manchester United Kingdom (GB) Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS) India (IN) Istanbul University / İstanbul Üniversitesi Turkey (TR) Royal Melbourne Hospital (RMH) Australia (AU) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Byramjee Jeejeebhoy Government Medical College & Sassoon General Hospital India (IN) Cairo University / جامعة القاهرة Egypt (EG) Fauji Foundation Hospital Pakistan (PK) Hl. Kliment Ochridski-Universität Sofia Bulgaria (BG) Instituto Mexicano del Seguro Social Mexico (MX) Karolinska Institute Sweden (SE) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona Spain (ES) King’s College London United Kingdom (GB) Leeds Teaching Hospitals NHS Trust United Kingdom (GB) Southport and Ormskirk Hospital NHS Trust United Kingdom (GB) Policlinico San Matteo Pavia Fondazione IRCCS Italy (IT) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB) Universitätsspital Zürich (USZ) Switzerland (CH) University of Pittsburgh United States (USA) (US)

How to cite

APA:

Yoshida, A., Kim, M., Kuwana, M., Ravichandran, N., Makol, A., Sen, P.,... Gupta, L. (2022). Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey. Rheumatology. https://doi.org/10.1093/rheumatology/keac441

MLA:

Yoshida, Akira, et al. "Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey." Rheumatology (2022).

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