Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals

Luehr I, Friedl A, Overath T, Tholey A, Kunze T, Hilpert F, Sebens S, Arnold N, Roesel F, Oberg HH, Maass N, Mundhenke C, Jonat W, Bauer M (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Cancer Letters Elsevier

Book Volume: 325

Pages Range: 175-188

Journal Issue: 2

DOI: 10.1016/j.canlet.2012.06.014

Abstract

Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy. © 2012 Elsevier Ireland Ltd.

Authors with CRIS profile

Christoph Mundhenke

Involved external institutions

Christian-Albrechts-Universität zu Kiel DE Germany (DE) University of Wisconsin - Madison US United States (USA) (US) Universitätsklinikum Aachen (UKA) DE Germany (DE)

How to cite

APA:

Luehr, I., Friedl, A., Overath, T., Tholey, A., Kunze, T., Hilpert, F.,... Bauer, M. (2012). Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals. Cancer Letters, 325(2), 175-188. https://doi.org/10.1016/j.canlet.2012.06.014

MLA:

Luehr, Inke, et al. "Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals." Cancer Letters 325.2 (2012): 175-188.

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