Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, Mcculloch JA, Badger JH, Ajami NJ, Trinchieri G, De Villena FPM, Yewdell JW, Rehermann B (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 171
Pages Range: 1015-1028.e13
Journal Issue: 5
DOI: 10.1016/j.cell.2017.09.016
Abstract
Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living mammals. Because the microbiome is a major factor in mammalian physiology, we aimed to identify a naturally evolved reference microbiome to better recapitulate physiological phenomena relevant in the natural world outside the laboratory. Among 21 distinct mouse populations worldwide, we identified a closely related wild relative to standard laboratory mouse strains. Its bacterial gut microbiome differed significantly from its laboratory mouse counterpart and was transferred to and maintained in laboratory mice over several generations. Laboratory mice reconstituted with natural microbiota exhibited reduced inflammation and increased survival following influenza virus infection and improved resistance against mutagen/inflammation-induced colorectal tumorigenesis. By demonstrating the host fitness-promoting traits of natural microbiota, our findings should enable the discovery of protective mechanisms relevant in the natural world and improve the modeling of complex diseases of free-living mammals. Video Abstract Characterization of a wild mice reference microbiome opens a window of opportunity to understand how the gut microbiota affects aspects of host physiology that are important in the natural world outside the laboratory.
Authors with CRIS profile
Involved external institutions
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK / NIDDKD)
United States (USA) (US)
US National Institutes of Health (NIH)
United States (USA) (US)
Houston Texas Medical Center
United States (USA) (US)
University of North Carolina at Chapel Hill
United States (USA) (US)
Food and Drug Administration (FDA / USFDA)
United States (USA) (US)
National Cancer Institute (NCI)
United States (USA) (US)
United States (USA) (US)
US National Institutes of Health (NIH)
United States (USA) (US)
Houston Texas Medical Center
United States (USA) (US)
University of North Carolina at Chapel Hill
United States (USA) (US)
Food and Drug Administration (FDA / USFDA)
United States (USA) (US)
National Cancer Institute (NCI)
United States (USA) (US)
How to cite
APA:
Rosshart, S.P., Vassallo, B.G., Angeletti, D., Hutchinson, D.S., Morgan, A.P., Takeda, K.,... Rehermann, B. (2017). Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell, 171(5), 1015-1028.e13. https://dx.doi.org/10.1016/j.cell.2017.09.016
MLA:
Rosshart, Stephan P., et al. "Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance." Cell 171.5 (2017): 1015-1028.e13.
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