Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment.
Fnu G, Weber GF (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 11
Abstract
We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and alters ion homeostasis. Among these features, the least elucidated component is ion homeostasis. Here we review the literature with the goal to infer a better mechanistic understanding of the progression-associated ionic alterations and identify the most promising drugs for treatment. Cancer metastasis is accompanied by skewing in calcium, zinc, copper, potassium, sodium and chloride homeostasis. Membrane potential changes and water uptake through Aquaporins may also play roles. Drug candidates to reverse these alterations are at various stages of testing, with some having entered clinical trials. Challenges to their utilization comprise differences among tumor types and the involvement of multiple ions in each case. Further, adverse effects may become a concern, as channel blockers, chelators, or supplemented ions will affect healthy and transformed cells alike.
Involved external institutions
United States (USA) (US)How to cite
APA:
Fnu, G., & Weber, G.F. (2021). Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment. Frontiers in Oncology, 11. https://dx.doi.org/10.3389/fonc.2021.765329
MLA:
Fnu, Gulimirerouzi, and Georg F. Weber. "Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment." Frontiers in Oncology 11 (2021).
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