Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development
Wöhner M, Tagoh H, Bilic I, Jaritz M, Poliakova DK, Fischer M, Busslinger M (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 213
Pages Range: 1201-1221
Journal Issue: 7
DOI: 10.1084/jem.20152002
Abstract
E2A is an essential regulator of early B cell development. Here, we have demonstrated that E2A together with E2-2 controlled germinal center (GC) B cell and plasma cell development. As shown by the identification of regulated E2A,E2-2 target genes in activated B cells, these E-proteins directly activated genes with important functions in GC B cells and plasma cells by inducing and maintaining DNase I hypersensitive sites. Through binding to multiple enhancers in the Igh 3' regulatory region and Aicda locus, E-proteins regulated class switch recombination by inducing both Igh germline transcription and AID expression. By regulating 3' Igk and Igh enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh, and Prdm1 activation in plasmablasts. Together, these data identified E2A and E2-2 as central regulators of B cell immunity.
Authors with CRIS profile
Involved external institutions
Vienna Biocenter VBC
Austria (AT)
Forschungsinstitut für Molekulare Pathologie / Research Institute of Molecular Pathology (IMP)
Austria (AT)
Austria (AT)
Forschungsinstitut für Molekulare Pathologie / Research Institute of Molecular Pathology (IMP)
Austria (AT)
How to cite
APA:
Wöhner, M., Tagoh, H., Bilic, I., Jaritz, M., Poliakova, D.K., Fischer, M., & Busslinger, M. (2016). Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development. Journal of Experimental Medicine, 213(7), 1201-1221. https://dx.doi.org/10.1084/jem.20152002
MLA:
Wöhner, Miriam, et al. "Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development." Journal of Experimental Medicine 213.7 (2016): 1201-1221.
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