The Effect of Exercise Intensity and Volume on Metabolic Phenotype in Patients with Metabolic Syndrome: A Randomized Controlled Trial
Von Korn P, Keating S, Mueller S, Haller B, Kraenkel N, Dinges S, Duvinage A, Scherr J, Wisloff U, Tjonna AE, Halle M, Lechner K (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 19
Pages Range: 107-114
Journal Issue: 2
Abstract
Background: Moderate intensity continuous training (MICT) ameliorates dysmetabolism in patients with metabolic syndrome (MetS). The impact of low-(1HIIT) versus high-volume high-intensity interval training (4HIIT) versus MICT on central adiposity, insulin resistance, and atherogenic dyslipidemia in patients with MetS has not yet been reported. Methods: Twenty-nine patients with MetS according to International Diabetes Federation criteria (nine females, age 61 ± 5 years, body mass index 31.1 ± 3.7 kg/m2, waist circumference (WC) 102.2 ± 10.6 cm, 108.5 ± 8.6 cm) were randomized (1:1:1) to 16 weeks of (1) MICT (5 × 30 min/week, 35%-50% heart rate reserve (HRR), (2) 1HIIT (3 × 17 min/week incl. 4 min @80%-90% HRR), and (3) 4HIIT (3 × 38 min/week incl. 4 × 4 min @80%-90% HRR). Peak oxygen uptake (V˙O2peak), WC and anthropometric/metabolic indices indicative of MetS, fasting glucose/insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), dyslipidemia, and respiratory exchange ratio (RER) at warm-up were quantified at baseline and study completion. Analysis of variance and paired t tests were used for statistical analysis. Analyses were performed after checking for parametric distribution. Results: There were no significant differences between groups in waist-To-height ratio (: Δ-0.10 ±-0.05, Δ-0.08 ±-0.06, P = 0.916), WC (: Δ-1.4 ±-0.1 cm, Δ0.1 ± 0.9 cm, P = 0.590), fasting glucose (Δ-1.18 ± 16.7 μU/mL, P = 0.773), fasting insulin (Δ0.76 ± 13.4 μU/mL, P = 0.509), HOMA-IR (Δ0.55 ± 4.1, P = 0.158), atherogenic dyslipidemia [triglycerides (TAG) Δ-10.1 ± 46.9 mg/dL, P = 0.468, high-density lipoprotein cholesterol (HDL-C) Δ1.5 ± 5.4, P = 0.665, TAG/HDL-C-0.19 ± 1.3, P = 0.502], V˙O2peak (P = 0.999), or RER (P = 0.842). In the entire group, waist-To-height-ratio and V˙O2peak significantly improved by a clinically meaningful amount (Δ2.7 ± 0.9 mL/min/kg; P < 0.001) and RER at warm-up significantly decreased (Δ-0.03 ± 0.06, P = 0.039). Conclusion: In patients with MetS, there was no significant difference between HIIT, irrespective of volume, to MICT for improving exercise capacity or metabolic health.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
University of Queensland
Australia (AU)
Charité - Universitätsmedizin Berlin
Germany (DE)
NTNU Trondheim - Norwegian University of Science and Technology
Norway (NO)
Germany (DE)
University of Queensland
Australia (AU)
Charité - Universitätsmedizin Berlin
Germany (DE)
NTNU Trondheim - Norwegian University of Science and Technology
Norway (NO)
How to cite
APA:
Von Korn, P., Keating, S., Mueller, S., Haller, B., Kraenkel, N., Dinges, S.,... Lechner, K. (2021). The Effect of Exercise Intensity and Volume on Metabolic Phenotype in Patients with Metabolic Syndrome: A Randomized Controlled Trial. Metabolic Syndrome and Related Disorders, 19(2), 107-114. https://doi.org/10.1089/met.2020.0105
MLA:
Von Korn, Pia, et al. "The Effect of Exercise Intensity and Volume on Metabolic Phenotype in Patients with Metabolic Syndrome: A Randomized Controlled Trial." Metabolic Syndrome and Related Disorders 19.2 (2021): 107-114.
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