Modeling the brain morphology distribution in the general aging population

Huizinga W, Poot DHJ, Roshchupkin G, Bron EE, Ikram MA, Vernooij MW, Rueckert D, Niessen WJ, Klein S (2016)

Publication Type: Conference contribution

Publication year: 2016

Journal

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Publisher: SPIE

Book Volume: 9788

Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Event location: San Diego, CA, USA

ISBN: 9781510600232

DOI: 10.1117/12.2207228

Abstract

Both normal aging and neurodegenerative diseases such as Alzheimer's disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the entire brain morphology distribution in the general aging population. The method is applied to 1000 subjects from a large population imaging study in the elderly, from which 900 were used to train the model and 100 were used for testing. The results of the 100 test subjects show that the model generalizes to subjects outside the model population. Smooth percentile curves showing the brain morphology changes as a function of age and spatiotemporal atlases derived from the model population are publicly available via an interactive web application at agingbrain.bigr.nl.

Involved external institutions

Erasmus University Medical Center (MC) NL Netherlands (NL) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Huizinga, W., Poot, D.H.J., Roshchupkin, G., Bron, E.E., Ikram, M.A., Vernooij, M.W.,... Klein, S. (2016). Modeling the brain morphology distribution in the general aging population. In Barjor Gimi, Andrzej Krol (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. San Diego, CA, USA: SPIE.

MLA:

Huizinga, W., et al. "Modeling the brain morphology distribution in the general aging population." Proceedings of the Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, USA Ed. Barjor Gimi, Andrzej Krol, SPIE, 2016.

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