Neutrophils self-limit swarming to contain bacterial growth in vivo
Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knoepper K, Reategui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmueller W, Laemmermann T (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 372
Article Number: eabe7729
Journal Issue: 6548
Abstract
Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism to self-limit swarming and avoid uncontrolled aggregation during inflammation. G protein-coupled receptor (GPCR) desensitization acts as a negative feedback control to stop migration of neutrophils when they sense high concentrations of self-secreted attractants that initially amplify swarming. Interference with this process allows neutrophils to scan larger tissue areas for microbes. Unexpectedly, this does not benefit bacterial clearance as containment of proliferating bacteria by neutrophil clusters becomes impeded. Our data reveal how autosignaling stops self-organized swarming behavior and how the finely tuned balance of neutrophil chemotaxis and arrest counteracts bacterial escape.
Involved external institutions
Max-Planck-Institut für Immunbiologie und Epigenetik (MPI-IE) / Max Planck Institute of Immunobiology and Epigenetics
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Harvard University
United States (USA) (US)
Universität Duisburg-Essen (UDE)
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Duke University
United States (USA) (US)
US National Institutes of Health (NIH)
United States (USA) (US)
Germany (DE)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Harvard University
United States (USA) (US)
Universität Duisburg-Essen (UDE)
Germany (DE)
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Duke University
United States (USA) (US)
US National Institutes of Health (NIH)
United States (USA) (US)
How to cite
APA:
Kienle, K., Glaser, K.M., Eickhoff, S., Mihlan, M., Knoepper, K., Reategui, E.,... Laemmermann, T. (2021). Neutrophils self-limit swarming to contain bacterial growth in vivo. Science, 372(6548). https://doi.org/10.1126/science.abe7729
MLA:
Kienle, Korbinian, et al. "Neutrophils self-limit swarming to contain bacterial growth in vivo." Science 372.6548 (2021).
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