Hüffmeier U, Klima J, Hayatu MD (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 35
Pages Range: 46-54
Journal Issue: 1
The psoriatic field includes both rare and common subtypes. Common complex forms include psoriasis vulgaris and psoriatic arthritis. In these subtypes, certain HLA alleles remain the most relevant genetic factors, although genome-wide association studies lead to the detection of more than 80 susceptibility loci. They mainly affect innate and adaptive immunity and explain over 28 % of the heritability. Pustular psoriasis comprises a group of rarer subtypes. Using exome sequencing, several disease genes were identified for mainly generalized pustular psoriasis, and an oligogenic inheritance is likely. Treatment studies based on the affected IL-36 pathway indicate a high response rate in this subtype further supporting the pathophysiological relevance of the affected gene products.
APA:
Hüffmeier, U., Klima, J., & Hayatu, M.D. (2023). Genetic underpinnings of the psoriatic spectrum. Medizinische Genetik, 35(1), 46-54. https://doi.org/10.1515/medgen-2023-2005
MLA:
Hüffmeier, Ulrike, Janine Klima, and Mohammad Deen Hayatu. "Genetic underpinnings of the psoriatic spectrum." Medizinische Genetik 35.1 (2023): 46-54.
BibTeX: Download