Patterns of progression differ between Kellgren-Lawrence 2 and 3 knees fulfilling different definitions of a cartilage-meniscus phenotype in the Foundation for National Institutes of Health Osteoarthritis Biomarkers study (FNIH).

Roemer FW, Collins JE, Hunter DJ, Demehri S, Guermazi A (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Osteoarthritis and Cartilage Open Elsevier

Book Volume: 4

Journal Issue: 3

DOI: 10.1016/j.ocarto.2022.100284

Abstract

OBJECTIVE: Aim was to describe three definitions for an MRI-defined cartilage-meniscus phenotype and to report phenotypic progression in Kellgren-Lawrence (KL) 2 and 3 knees over 48 months. METHODS: The study sample was a nested case-control study with knees showing either 1) radiographic and pain progression ("composite" case), 2) radiographic progression only, 3) pain progression only, and 4) no progression. MRI was performed on 3T systems. MRIs were read according to the MOAKS system. Knees were classified as having the cartilage-meniscus phenotype according to three modified ROAMES (Rapid OsteoArthritis MRI Eligibility Score) definitions (D): 1) ​≤ ​2.2 (10-75% of the region of cartilage surface area with 10-75% affected by full thickness loss), i.e. 'D1' 2) ≤ 2.1 (10-75% of the region of cartilage surface area with <10% affected by full thickness loss), i.e. 'D2' and 3) ≤ 2.0 (10-75% of the region of cartilage surface area without full thickness loss), i.e. 'D3'. The odds of being a composite case for those with vs. without each definition was determined using logistic regression. RESULTS: 485 knees were included. For KL2 knees 191 (64%) knees fulfilled D1 criteria, 183 (62%) D2 and 167 (56%) D3. For KL3 these numbers were 164 (87%), 103 (55%) and 77 (41%). Odds for being a composite case for KL2 knees were 2.52 (95% CI 1.40,4.54) for D1, 1.93 (95% CI 1.11,3.35) for D2 and 1.92 (95% CI 1.13,3.28) for D3. For KL3 knees odds were 0.32 (95% CI 0.13,0.78) for D1, 0.56 (95% CI 0.31,1.01) for D2 and 0.49 (95% CI 0.26,0.91) for D3. CONCLUSION: Increased odds for progression are seen for KL2 knees for all definitions, while this was not observed for KL3 knees. KL3 knees exceeding the maximum damage thresholds and not fulfilling the phenotypic definitions are still likely to experience further progression.

Authors with CRIS profile

Frank Roemer

Involved external institutions

Brigham and Women's Hospital (BWH) US United States (USA) (US) Kolling Institute AU Australia (AU) Boston University US United States (USA) (US) Johns Hopkins University (JHU) US United States (USA) (US)

How to cite

APA:

Roemer, F.W., Collins, J.E., Hunter, D.J., Demehri, S., & Guermazi, A. (2022). Patterns of progression differ between Kellgren-Lawrence 2 and 3 knees fulfilling different definitions of a cartilage-meniscus phenotype in the Foundation for National Institutes of Health Osteoarthritis Biomarkers study (FNIH). Osteoarthritis and Cartilage Open, 4(3). https://doi.org/10.1016/j.ocarto.2022.100284

MLA:

Roemer, Frank Wolfgang, et al. "Patterns of progression differ between Kellgren-Lawrence 2 and 3 knees fulfilling different definitions of a cartilage-meniscus phenotype in the Foundation for National Institutes of Health Osteoarthritis Biomarkers study (FNIH)." Osteoarthritis and Cartilage Open 4.3 (2022).

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