Probing the chemo-mechanical effects of an anti-cancer drug emodin on breast cancer cells

Wuang SC, Ladoux B, Lim CT (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Cellular and Molecular Bioengineering Springer Verlag (Germany)

Book Volume: 4

Pages Range: 466-475

Journal Issue: 3

DOI: 10.1007/s12195-011-0163-1

Abstract

The anti-cancer drug, emodin, can cause significant mechanobiological changes in human cancer cells, due to the interplay of anti-cell adhesion, actin-disrupting and apoptosis-causing effects of the drug. Here, we used micropillars to monitor the changes in traction forces induced by breast cancer cells in response to this drug stimulus. Our results showed that the variations in the cell traction forces reflected changes in the cytoskeleton integrity and cell behavior. Cell traction forces were found to increase during cell rounding and decrease during the onset of apoptosis and cytoskeleton disruption. These results can provide useful insights into the chemo-mechanical relationships arising from the cell-matrix interactions and can potentially help in the quantitative assessment of drug efficacy. © 2011 Biomedical Engineering Society.

Authors with CRIS profile

Benoit Ladoux

Involved external institutions

National University of Singapore (NUS) SG Singapore (SG) University of Paris 7 - Denis Diderot / Université Paris VII Denis Diderot FR France (FR)

How to cite

APA:

Wuang, S.C., Ladoux, B., & Lim, C.T. (2011). Probing the chemo-mechanical effects of an anti-cancer drug emodin on breast cancer cells. Cellular and Molecular Bioengineering, 4(3), 466-475. https://doi.org/10.1007/s12195-011-0163-1

MLA:

Wuang, Shy Chyi, Benoit Ladoux, and Chwee Teck Lim. "Probing the chemo-mechanical effects of an anti-cancer drug emodin on breast cancer cells." Cellular and Molecular Bioengineering 4.3 (2011): 466-475.

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