Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig

von Wilmowsky C, Stockmann P, Harsch I, Amann KU, Metzler P, Lutz R, Möst T, Neukam FW, Schlegel KA (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Journal of Clinical Periodontology Wiley-Blackwell

Book Volume: 38

Pages Range: 771-779

Journal Issue: 8

DOI: 10.1111/j.1600-051X.2011.01746.x

Abstract

Aim: Diabetes mellitus is classified as a relative contraindication for implant treatment, and higher failure rates have been seen in diabetic patients. The aim of the present study was to investigate the effect of diabetes on peri-implant bone formation in an animal model of human bone repair. Materials and Methods: Diabetes was induced by an intra-venous application of streptozotocin (90 mg/kg) in 15 domestic pigs. Implants were placed after significant histopathological changes in the hard and soft tissues were verified. The bone-implant contact (BIC), peri-implant bone mineral density (BMD), and expression of collagen type-I and osteocalcin proteins were qualitatively evaluated 4 and 12 weeks after implantation. Fifteen animals served as healthy controls. Results: Diabetes caused pathological changes in the soft and hard tissues. The BIC and BMD were significantly reduced in the diabetic group after 4 and 12 weeks. Collagen type-I was increased in the diabetic group at both time points, whereas osteocalcin was reduced in the diabetic group. Conclusions: Poorly controlled diabetes negatively affects peri-implant bone formation and bone mineralization. These findings have to be taken into consideration for diabetic patients with an indication for implant therapy. © 2011 John Wiley & Sons A/S.

Authors with CRIS profile

Cornelius von Wilmowsky Department of Oral and Cranio-Maxillofacial Surgery Philipp Stockmann Medizinische Fakultät Kerstin Ute Amann Professur für Nephropathologie Rainer Lutz Department of Oral and Cranio-Maxillofacial Surgery Tobias Möst Department of Oral and Cranio-Maxillofacial Surgery Friedrich Wilhelm Neukam Medizinische Fakultät

How to cite

APA:

von Wilmowsky, C., Stockmann, P., Harsch, I., Amann, K.U., Metzler, P., Lutz, R.,... Schlegel, K.A. (2011). Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig. Journal of Clinical Periodontology, 38(8), 771-779. https://doi.org/10.1111/j.1600-051X.2011.01746.x

MLA:

von Wilmowsky, Cornelius, et al. "Diabetes mellitus negatively affects peri-implant bone formation in the diabetic domestic pig." Journal of Clinical Periodontology 38.8 (2011): 771-779.

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