Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons
Kochan SM, Malo MC, Jevtic M, Jahn-Kelleter HM, Wani GA, Ndoci K, Pérez-Revuelta L, Gaedke F, Schäffner I, Lie DC, Schauss A, Bergami M (2024)
Publication Type: Journal article
Publication year: 2024
Journal
DOI: 10.1016/j.neuron.2024.03.013
Abstract
Integration of new neurons into adult hippocampal circuits is a process coordinated by local and long-range synaptic inputs. To achieve stable integration and uniquely contribute to hippocampal function, immature neurons are endowed with a critical period of heightened synaptic plasticity, yet it remains unclear which mechanisms sustain this form of plasticity during neuronal maturation. We found that as new neurons enter their critical period, a transient surge in fusion dynamics stabilizes elongated mitochondrial morphologies in dendrites to fuel synaptic plasticity. Conditional ablation of fusion dynamics to prevent mitochondrial elongation selectively impaired spine plasticity and synaptic potentiation, disrupting neuronal competition for stable circuit integration, ultimately leading to decreased survival. Despite profuse mitochondrial fragmentation, manipulation of competition dynamics was sufficient to restore neuronal survival but left neurons poorly responsive to experience at the circuit level. Thus, by enabling synaptic plasticity during the critical period, mitochondrial fusion facilitates circuit remodeling by adult-born neurons.
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Germany (DE)How to cite
APA:
Kochan, S.M., Malo, M.C., Jevtic, M., Jahn-Kelleter, H.M., Wani, G.A., Ndoci, K.,... Bergami, M. (2024). Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons. Neuron. https://doi.org/10.1016/j.neuron.2024.03.013
MLA:
Kochan, Sandra M.V., et al. "Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons." Neuron (2024).
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