Mechanisms Underlying Inflammation in Neurodegeneration
Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010)
Publication Type: Journal article, Review article
Publication year: 2010
Journal
Book Volume: 140
Pages Range: 918-934
Journal Issue: 6
DOI: 10.1016/j.cell.2010.02.016
Abstract
Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Although inducers of inflammation may be generated in a disease-specific manner, there is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators. A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. © 2010 Elsevier Inc.
Authors with CRIS profile
Involved external institutions
UC San Diego School of Medicine
United States (USA) (US)
Salk Institute for Biological Studies
United States (USA) (US)
United States (USA) (US)
Salk Institute for Biological Studies
United States (USA) (US)
How to cite
APA:
Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., & Gage, F.H. (2010). Mechanisms Underlying Inflammation in Neurodegeneration. Cell, 140(6), 918-934. https://doi.org/10.1016/j.cell.2010.02.016
MLA:
Glass, Christopher K., et al. "Mechanisms Underlying Inflammation in Neurodegeneration." Cell 140.6 (2010): 918-934.
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