Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative
Moradi K, Mohajer B, Mohammadi S, Guermazi A, Ibad HA, Roemer FW, Cao X, Link TM, Demehri S (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Book Volume: 32
Pages Range: 1154-1162
Journal Issue: 9
DOI: 10.1016/j.joca.2024.05.013
Abstract
Objectives: Sex of patients with knee osteoarthritis (KOA) may impact changes in thigh muscle composition during weight loss, the most well-known disease-modifying intervention. We investigated longitudinal sex-based changes in thigh muscle quality during weight loss in participants with KOA. Methods: Using Osteoarthritis Initiative (OAI) cohort data, we included females and males with baseline radiographic KOA who experienced > 5 % reduction in Body Mass Index (BMI) over four years. Using a previously validated deep-learning algorithm, we measured Magnetic Resonance Imaging (MRI)-derived biomarkers of thigh muscles at baseline and year-4. Outcomes were the intra- and inter-muscular adipose tissue (Intra-MAT and Inter-MAT) and contractile percentage of thigh muscles between females and males. The analysis adjusted for potential confounders, such as demographics, risk factors, BMI change, physical activity, diet, and KOA status. Results: A retrospective selection of available thigh MRIs from KOA participants who also had a 4-year weight loss (>5 % of BMI) yielded a sample comprising 313 thighs (192 females and 121 males). Female and male participants exhibited a comparable degree of weight loss (females: −9.72 ± 4.38, males: −8.83 ± 3.64, P-value=0.060). However, the changes in thigh muscle quality were less beneficial for females compared to males, as shown by a less degree of longitudinal decrease in Intra-MAT (change difference,95 %CI: 783.44 mm2/4-year, 505.70 to 1061.19, P-value<0.001) and longitudinal increase in contractile percentage (change difference,95 %CI: −3.9 %/4-year, −6.5 to −1.4, P-value=0.019). Conclusions: In participants with KOA and 4-year weight loss, the longitudinal changes in thigh muscle quality were overall beneficial but to a less degree in females compared to males. Further research is warranted to investigate the underlying mechanisms and develop sex-specific interventions to optimize muscle quality during weight loss.
Involved external institutions
Johns Hopkins Hospital
United States (USA) (US)
Tehran University of Medical Sciences (TUMS) / دانشگاه علوم پزشکی تهران
Iran, Islamic Republic of (IR)
Boston University
United States (USA) (US)
University of California San Francisco (UCSF)
United States (USA) (US)
United States (USA) (US)
Tehran University of Medical Sciences (TUMS) / دانشگاه علوم پزشکی تهران
Iran, Islamic Republic of (IR)
Boston University
United States (USA) (US)
University of California San Francisco (UCSF)
United States (USA) (US)
How to cite
APA:
Moradi, K., Mohajer, B., Mohammadi, S., Guermazi, A., Ibad, H.A., Roemer, F.W.,... Demehri, S. (2024). Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative. Osteoarthritis and Cartilage, 32(9), 1154-1162. https://doi.org/10.1016/j.joca.2024.05.013
MLA:
Moradi, Kamyar, et al. "Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative." Osteoarthritis and Cartilage 32.9 (2024): 1154-1162.
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