Cell-penetrating and neurotargeting dendritic siRNA nanostructures
Brunner K, Harder J, Halbach T, Willibald J, Spada F, Gnerlich F, Sparrer K, Beil A, Möckl L, Bräuchle C, Conzelmann KK, Carell T (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 54
Pages Range: 1946-1949
Journal Issue: 6
Abstract
We report the development of dendritic siRNA nanostructures that are able to penetrate even difficult to transfect cells such as neurons with the help of a special receptor ligand. The nanoparticles elicit strong siRNA responses, despite the dendritic structure. An siRNA dendrimer directed against the crucial rabies virus (RABV) nucleoprotein (N protein) and phosphoprotein (P protein) allowed the suppression of the virus titer in neurons below the detection limit. The cell-penetrating siRNA dendrimers, which were assembled using click chemistry, open up new avenues toward finding novel molecules able to cure this deadly disease.
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Germany (DE)How to cite
APA:
Brunner, K., Harder, J., Halbach, T., Willibald, J., Spada, F., Gnerlich, F.,... Carell, T. (2015). Cell-penetrating and neurotargeting dendritic siRNA nanostructures. Angewandte Chemie International Edition, 54(6), 1946-1949. https://doi.org/10.1002/anie.201409803
MLA:
Brunner, Korbinian, et al. "Cell-penetrating and neurotargeting dendritic siRNA nanostructures." Angewandte Chemie International Edition 54.6 (2015): 1946-1949.
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