The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype

Ziegler P, Hartkopf AD, Wallwiener M, Häberle L, Kolberg HC, Hadji P, Tesch H, Ettl J, Lüftner D, Müller V, Michel LL, Belleville E, Wimberger P, Hielscher C, Hübner H, Uhrig S, Wurmthaler L, Hack C, Mundhenke C, Kurbacher C, Fasching P, Wuerstlein R, Untch M, Janni W, Taran FA, Lux MP, Wallwiener D, Brucker SY, Fehm TN, Schneeweiss A, Goossens C (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Book Volume: 24

Article Number: 1284

Journal Issue: 1

DOI: 10.1186/s12885-024-13038-3

Abstract

Background: Although adequate physical activity has been shown to be beneficial in early breast cancer, evidence in metastatic breast cancer is sparse and contradictory, which could be related to distinct effects of physical activity on the different molecular cancer subtypes. Therefore, we here evaluated the effect of physical activity on progression-free and overall survival (PFS, OS) in metastatic breast cancer, specifically looking at molecular subtypes. Methods: International Physical Activity Questionnaire (IPAQ) questionnaires, filled out by patients enrolled in the prospective PRAEGNANT registry (NCT02338167; n = 1,270) were used to calculate metabolic equivalent task (MET) minutes, which were subsequently categorized into low (n = 138), moderate (n = 995) or high IPAQ categories (n = 137). Cox regression analyses were used to evaluate the impact of IPAQ categories and its interaction with molecular subtypes on PFS and OS. Results: Patient and tumor characteristics were equally distributed across IPAQ categories. HER2pos, HRpos and TNBC were present in 23.1%, 65.7% and 11.2% of patients, respectively. IPAQ scores did not have an impact on PFS and OS in addition to established prognostic factors, either overall or in particular molecular subtypes (PFS: p = 0.33 and OS: p = 0.08, likelihood ratio test). Exploratory analyses showed higher overall survival rates for high IPAQ categories compared to low/moderate IPAQ categories in luminal B-like breast cancer. Conclusions: Self-reported physical activity using the IPAQ questionnaire did not significantly affect PFS or OS in patients suffering from metastatic breast cancer. Nevertheless, some hypothesis-generating differences between molecular subtypes could be observed, which may be interesting to evaluate further.

Authors with CRIS profile

Involved external institutions

HELIOS Kliniken Germany (DE) Universitätsklinikum Ulm Germany (DE) Universitätsklinikum Freiburg Germany (DE) St. Vincenz-Krankenhaus Germany (DE) Universitätsklinikum Tübingen Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Frankfurter Hormon und Osteoporosezentrum Germany (DE) Agaplesion Markus Krankenhaus Germany (DE) Klinikum rechts der Isar Germany (DE) Heinrich-Heine-Universität Düsseldorf Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) Germany (DE) Marienhospital Bottrop Germany (DE) Klinikum der Universität München Germany (DE) Klinikum Bayreuth Germany (DE) Medizinische Hochschule Brandenburg "Theodor Fontane" / Brandenburg Medical School "Theodor Fontane" Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) ClinSol GmbH & Co.KG Germany (DE) Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) Gynäkologie Kompetenzzentrum Stralsund: gSUND Germany (DE)

How to cite

APA:

Ziegler, P., Hartkopf, A.D., Wallwiener, M., Häberle, L., Kolberg, H.C., Hadji, P.,... Goossens, C. (2024). The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype. BMC Cancer, 24(1). https://doi.org/10.1186/s12885-024-13038-3

MLA:

Ziegler, Philipp, et al. "The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype." BMC Cancer 24.1 (2024).

BibTeX: Download