Inflammatory Signals Across the Spectrum: A Detailed Exploration of Acute Appendicitis Stages According to EAES 2015 Guidelines

Dölling M, Andric M, Rahimli M, Klös M, Pachmann J, Stockheim J, Al-Madhi S, Wex C, Kahlert UD, Herrmann M, Perrakis A, Croner RS (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Diagnostics MDPI

Book Volume: 14

Article Number: 2335

Journal Issue: 20

DOI: 10.3390/diagnostics14202335

Abstract

Background: In this retrospective study, we evaluate the diagnostic utility of C-reactive protein (CRP) and leucocyte count within the EAES 2015 guidelines for acute appendicitis (AA) in differentiating uncomplicated (UAA) from complicated AA (CAA). Methods: Conducted at a tertiary care center in Germany, the study included 285 patients over 18 years who were diagnosed with AA from January 2019 to December 2021. Patient data included demographics, inflammatory markers, and postoperative outcomes. Results: CRP levels (Md: 60.2 mg/dL vs. 10.5 mg/dL; p < 0.001) and leucocyte count (Md: 14.4 Gpt/L vs. 13.1 Gpt/L; p = 0.016) were higher in CAA. CRP had a medium diagnostic value for detecting CAA (AUC = 0.79), with a cutoff at 44.3 mg/L, making it more likely to develop CAA. Leucocyte count showed low predictive value for CAA (AUC = 0.59). CRP ≥ 44.3 mg/L was associated with a higher risk of postoperative complications (OR: 2.9; p = 0.002) and prolonged hospitalization (OR: 3.5; p < 0.001). Conclusions: CRP, within the context of the EAES classification, presents as a valuable diagnostic marker to distinguish CAA from UAA, with a higher risk of postoperative complications and hospitalization. Leucocyte count showed low diagnostic value for the identification of CAA.

Involved external institutions

Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE)

How to cite

APA:

Dölling, M., Andric, M., Rahimli, M., Klös, M., Pachmann, J., Stockheim, J.,... Croner, R.S. (2024). Inflammatory Signals Across the Spectrum: A Detailed Exploration of Acute Appendicitis Stages According to EAES 2015 Guidelines. Diagnostics, 14(20). https://doi.org/10.3390/diagnostics14202335

MLA:

Dölling, Maximilian, et al. "Inflammatory Signals Across the Spectrum: A Detailed Exploration of Acute Appendicitis Stages According to EAES 2015 Guidelines." Diagnostics 14.20 (2024).

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