Architectural crypt distortions in ulcerative colitis: Time for reappraisal

Rubio CA, Lang-Schwarz C, Vieth M (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Journal of Gastroenterology and Hepatology Wiley-Blackwell

Book Volume: 39

Pages Range: 2479-2486

Journal Issue: 12

DOI: 10.1111/jgh.16811

Abstract

Chronic mucosal inflammation and architectural crypt distortions (ACD) are essential for the histologic diagnosis of ulcerative colitis (UC). ACD in UC has been defined as irregularly arranged, dilated, branched, and shortened crypts with inequality of inter-crypt distance. However, neither the diagnostic sections' crypt phenotype nor the cutting mode have been considered. In this regard, previous studies showed that most diagnostic biopsies in UC are fortuitously crosscut at laboratories. In this communication, we review the crypt phenotypes that are included in the ACD in UC notion: crypts in asymmetric branching, crypt rings in tandem, crypts with lateral buds, face-to-face “kissing crypts,” crypts-in-crypts, laterally orientated crypts in anthemia fold domains, and crypts with irregular shape and size in innominate groves domains. The awareness that disparate crypt phenotypes may participate in the ACD notion may open new vistas in the interpretation of crypt distortions in crosscut diagnostic sections in UC. The present findings will permit endoscopists and clinicians to better understand the narrative of ACD in the pathological diagnosis.

Authors with CRIS profile

Corinna Lang-Schwarz Institute of Pathology Michael Vieth Professur für Allgemeine Pathologie am Medizincampus Oberfranken

Involved external institutions

Karolinska Institute SE Sweden (SE)

How to cite

APA:

Rubio, C.A., Lang-Schwarz, C., & Vieth, M. (2024). Architectural crypt distortions in ulcerative colitis: Time for reappraisal. Journal of Gastroenterology and Hepatology, 39(12), 2479-2486. https://doi.org/10.1111/jgh.16811

MLA:

Rubio, Carlos A., Corinna Lang-Schwarz, and Michael Vieth. "Architectural crypt distortions in ulcerative colitis: Time for reappraisal." Journal of Gastroenterology and Hepatology 39.12 (2024): 2479-2486.

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