Efficacy of radiotherapy combined with atezolizumab or docetaxel in patients with previously treated NSCLC

Xu J, Wang H, Zhang C, Jin SH, Chen X, Tan F, Frey B, Hecht M, Sun JG, Gaipl U, Ma H, Zhou JG (2024)

Publication Type: Journal article

Publication year: 2024

Journal

iScience Elsevier

Book Volume: 27

Article Number: 111363

Journal Issue: 12

DOI: 10.1016/j.isci.2024.111363

Abstract

Radiotherapy showed synergy with immunotherapy, yet the comparative effectiveness of combining immunotherapy (iRT) or chemotherapy (CRT) after platinum therapy failure in advanced non-small cell lung cancer (NSCLC) remains unexplored. We analyzed 163 patients (iRT: n = 120 vs. CRT: n = 43) eligible for combination radiotherapy. Before matching, median overall survival (OS) was significantly longer in iRT group (7.79 vs. 4.57 months, hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.41–0.94, p = 0.024). After 1:2 propensity score matching (PSM) and inverse probability of treatment weighting (IPTW), iRT group showed improved OS, consistent with unmatched analysis (PSM, p = 0.033 and IPTW, p = 0.035). Exploratory analysis suggested that PD1+, central memory PD1+, and effector memory PD-L1+ CD4+ T cells were strong predictive biomarkers for iRT-treated patients (POS = 0.025, POS = 0.002, POS = 0.010, respectively). Proliferative CD4+ T celllow was a prognostic (POS = 0.008) and predictive biomarker for iRT (POS < 0.001). Our work revealed iRT was prolonged OS in previously treated advanced NSCLC patients. Additionally, proliferative CD4+ T cell served as prognostic and predictive biomarkers.

Authors with CRIS profile

Benjamin Frey Department of Radiation Oncology Udo Gaipl Department of Radiation Oncology

Involved external institutions

National Cancer Institute (NCI) US United States (USA) (US) Universitätsklinikum des Saarlandes (UKS) DE Germany (DE) Zunyi Medical University CN China (CN) AstraZeneca UK Limited GB United Kingdom (GB) Harrisburg University of Science and Technology US United States (USA) (US) Chongqing University Cancer Hospital CN China (CN)

How to cite

APA:

Xu, J., Wang, H., Zhang, C., Jin, S.H., Chen, X., Tan, F.,... Zhou, J.G. (2024). Efficacy of radiotherapy combined with atezolizumab or docetaxel in patients with previously treated NSCLC. iScience, 27(12). https://doi.org/10.1016/j.isci.2024.111363

MLA:

Xu, Junzhu, et al. "Efficacy of radiotherapy combined with atezolizumab or docetaxel in patients with previously treated NSCLC." iScience 27.12 (2024).

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