Facile Synthesis of New Antiviral Fluoro-Quinazolines Enabled by Merging Domino Reactions
Kohlbauer S, Xia H, Grau B, Wangen C, Hahn F, Nenajdenko VG, Marschall M, Tsogoeva S (2025)
Publication Language: English
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 57
Pages Range: 389-396
Journal Issue: 02
Abstract
Quinazolines, particularly fluoro-quinazolines, represent important structural motifs in bioactive molecules and pharmaceuticals. Despite several known synthetic routes, the efficient synthesis of fluorine-containing quinazolines remains a challenge. Herein, the straightforward and sustainable synthesis of fluorine-substituted quinazolines using domino sequences is reported. The obtained novel fluoro-quinazoline compounds exhibit significant in vitro activity against human cytomegalovirus (HCMV), expanding the library of potential antiviral drug compounds. Our finding outlays the synthetic toolkit for fluoro-quinazolines and introduces new agents for HCMV therapy.
Authors with CRIS profile
Sascha Kohlbauer
Lehrstuhl für Organische Chemie I
Benedikt Grau
Lehrstuhl für Organische Chemie I
Friedrich Hahn
Institute of Clinical and Molecular Virology
Manfred Marschall
Institute of Clinical and Molecular Virology
Svetlana Tsogoeva
Professur für Organische Chemie
Involved external institutions
Russian Federation (RU)How to cite
APA:
Kohlbauer, S., Xia, H., Grau, B., Wangen, C., Hahn, F., Nenajdenko, V.G.,... Tsogoeva, S. (2025). Facile Synthesis of New Antiviral Fluoro-Quinazolines Enabled by Merging Domino Reactions. Synthesis (Germany), 57(02), 389-396. https://doi.org/10.1055/s-0043-1775411
MLA:
Kohlbauer, Sascha, et al. "Facile Synthesis of New Antiviral Fluoro-Quinazolines Enabled by Merging Domino Reactions." Synthesis (Germany) 57.02 (2025): 389-396.
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