De-novo generation of vascularized tissue using different configurations of vascular pedicles in perforated and closed chambers De-novo Generierung von vaskularisiertem Gewebe mittels unterschiedlicher Gefässstielkonfigurationen in perforierten und geschlossenen Wachstumskammern

Dolderer JH, Kehrer A, Schiller SM, Schröder UH, Kohler K, Schaller HE, Siegel-Axel D (2010)

Publication Type: Journal article

Publication year: 2010

Journal

Wiener Medizinische Wochenschrift Springer Verlag

Book Volume: 160

Pages Range: 139-146

Journal Issue: 5-6

DOI: 10.1007/s10354-009-0734-0

Abstract

Growing three-dimensional tissue within a chamber requires vigorous angiogenesis initiated by, for example, an arteriovenous fistula or a ligated vascular pedicle. Growth may also be enhanced by contact with the external environment. In this study tissue growth in a rat model, vascularized via an arteriovenous loop (AV Loop) or ligated pedicle, was compared in chambers that were either closed or perforated. Chambers were harvested at 4 weeks and tissue volume and histology compared. In perforated chambers, more tissue were generated using the ligated pedicle (0.75 ml∼0.04) than the AV Loop (0.59 ml∼0.01). Perforated chambers generated larger volumes of tissue than closed chambers because they encouraged tissue ingrowth through the perforations. Both vessel configurations supported tissue growth but, interestingly, the ligated pedicle resulted in significantly more tissue in the perforated chambers.© Springer-Verlag 2010.

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE) Leibniz-Institut für Neurobiologie (LIN) DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE) Universitätsklinikum Tübingen DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE)

How to cite

APA:

Dolderer, J.H., Kehrer, A., Schiller, S.M., Schröder, U.H., Kohler, K., Schaller, H.E., & Siegel-Axel, D. (2010). De-novo generation of vascularized tissue using different configurations of vascular pedicles in perforated and closed chambers De-novo Generierung von vaskularisiertem Gewebe mittels unterschiedlicher Gefässstielkonfigurationen in perforierten und geschlossenen Wachstumskammern. Wiener Medizinische Wochenschrift, 160(5-6), 139-146. https://doi.org/10.1007/s10354-009-0734-0

MLA:

Dolderer, Jürgen H., et al. "De-novo generation of vascularized tissue using different configurations of vascular pedicles in perforated and closed chambers De-novo Generierung von vaskularisiertem Gewebe mittels unterschiedlicher Gefässstielkonfigurationen in perforierten und geschlossenen Wachstumskammern." Wiener Medizinische Wochenschrift 160.5-6 (2010): 139-146.

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