Molecular Radiation Biology

Reindl J, Abrantes AM, Ahire V, Azimzadeh O, Baatout S, Baeyens A, Baselet B, Chauhan V, Da Pieve F, Delbart W, Dobney CP, Edin NFJ, Falk M, Foray N, François A, Frelon S, Gaipl U, Georgakilas AG, Guipaud O, Hausmann M, Michaelidesova AJ, Kadhim M, Marques IA, Milic M, Mistry D, Moertl S, Montoro A, Obrador E, Pires AS, Quintens R, Rajan N, Rödel F, Rogan P, Savu D, Schettino G, Tabury K, Terzoudi GI, Triantopoulou S, Viktorsson K, Wozny AS (2023)

Publication Type: Authored book

Publication year: 2023

Publisher: Springer International Publishing

ISBN: 9783031188107

DOI: 10.1007/978-3-031-18810-7_3

Abstract

Various exogeneous and endogenous factors constantly cause damages in the biomolecules within a cell. For example, per day, 10,000-100,000 molecular lesions occur in DNA per cell. The molecule modifications that are formed disturb the structure and function of the affected molecules. The purpose of this chapter is to introduce the damages to biomolecules caused by radiation, the associated repair pathways, and the effect on the cellular function. Special interest lies on the damages induced to DNA, the carrier of the human genome, and the consequence to genomic integrity, cell death, and cell survival. Additionally, related effects regarding inflammation and immunity, epigenetic factors, and omics are discussed. The chapter concludes with an explanation of the molecular factors of cellular hyper-radiosensitivity and induced radiation resistance.

Authors with CRIS profile

Involved external institutions

National Technical University of Athens / Εθνικό Μετσόβιο Πολυτεχνείο Greece (GR) Belgian Nuclear Research Centre (SCK•CEN) / Studiecentrum voor Kernenergie / Centre d'Étude de l'énergie Nucléaire Belgium (BE) Universiteit Gent (UGent) / Ghent University Belgium (BE) Institut de radioprotection et de sûreté nucléaire (IRSN) France (FR) Ruprecht-Karls-Universität Heidelberg Germany (DE) Czech Technical University in Prague / České vysoké učení technické v Praze Czech Republic (CZ) Oxford Brookes University United Kingdom (GB) Universidade de Coimbra Portugal (PT) Royal Belgian Institute for Space Aeronomy / Koninklijk Belgisch Instituut voor Ruimte-Aeronomie Belgium (BE) Brussels University Hospital (H.U.B) / Hôpital Universitaire de Bruxelles Belgium (BE) University of Toronto Canada (CA) Institute for Medical Research and Occupational Health Croatia (HR) Bundesamt für Strahlenschutz (BfS) Germany (DE) University of València / Universitat de València Spain (ES) Hospital Universitario y Politécnico de La Fe Spain (ES) Karolinska Institute Sweden (SE) Université Claude Bernard Lyon 1 (UCB) France (FR) National Centre for Scientific Research (NCSR) "Demokritos" Greece (GR) University of Oslo Norway (NO) Czech Academy of Sciences, Institute of Biophysics / BFÚ AV ČR, Biofyzikální ústav AV ČR Czech Republic (CZ) National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) France (FR) Universität der Bundeswehr München Germany (DE) Goethe-Universität Frankfurt am Main Germany (DE) Western University Canada (CA) "Horia Hulubei" National Institute of Physics and Nuclear Engineering IFIN-HH Romania (RO)

How to cite

APA:

Reindl, J., Abrantes, A.M., Ahire, V., Azimzadeh, O., Baatout, S., Baeyens, A.,... Wozny, A.S. (2023). Molecular Radiation Biology. Springer International Publishing.

MLA:

Reindl, Judith, et al. Molecular Radiation Biology. Springer International Publishing, 2023.

BibTeX: Download