Ilyas K, Boccaccini AR (2022)
Publication Type: Authored book
Publication year: 2022
Publisher: wiley
ISBN: 9781119724193
DOI: 10.1002/9781119724193.ch12
Tissue engineering (TE) continues to encounter challenges, mainly associated with the effective interaction of biomaterials (scaffolds) with the human biological system. One important issue involves the design of biomaterials with enhanced biological properties and minimum rate of inflammation. Secondary metabolites extracted from medicinal plants are gaining attention for TE applications. In the last few years, research has been focused on the relatively novel approach of combining extracts from herbs (phytotherapeutic agents) with bioactive glasses (BGs) in order to achieve superior therapeutic effects and to modulate the biological performance of the resulting organic-inorganic systems for TE purposes. In this chapter, we present an overview of such BG-phytotherapeutic systems. The focus is on the development of phytotherapeutic compound incorporated BGs with superior biological activities. Summarizing research carried out on this type of organic-inorganic biomaterials, possible therapeutic applications of plant derived compounds (for example neem, curcumin, coumarin, daidzein, icariin, and lawsone) in combination with BGs are critically discussed. Moreover, the synergistic effects of phytotherapeutic agents and BG dissolution products on the biological properties of the new organic-inorganic systems are overviewed. It has been revealed that multifunctional combinations of BGs with phytotherapeutic compounds have great potential for both bone and soft TE. Systematic (in vivo) studies are required to assess the effective time dependent mutual biological effects of BGs and phytotherapeutic drugs in realistic conditions. Overall, the strategy of combining the properties of BGs with phytochemicals represents a cutting-edge approach toward the development of advanced biomaterials to promote tissue healing and/or regeneration.
APA:
Ilyas, K., & Boccaccini, A.R. (2022). Enhancing the biological performance of bioactive glasses by combination with phytotherapeutic compounds. wiley.
MLA:
Ilyas, Kanwal, and Aldo R. Boccaccini. Enhancing the biological performance of bioactive glasses by combination with phytotherapeutic compounds. wiley, 2022.
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