Huber C, Hageroth L, Meyer C, Ermert H, Ullmann I, Vossiek M, Lyer S (2024)
Publication Type: Journal article
Publication year: 2024
Book Volume: 10
Pages Range: 328-331
Issue: 4
Drug-loaded magnetic nanoparticles (MNPs) ac-cumulated by an external magnetic field already showed theirefficacy in localized tumor treatment in animal studies. Fur-thermore, specific MNPs are sonosensitive, enabling them togenerate inertial cavitation when exposed to a focused ultra-sound field. This can be used for controlling drug release, aswell as for particle detection and mapping. In addition to in-ertial cavitation, stable cavitation is also a part of the cavi-tation process, which has not yet been evaluated on MNPs.While stable cavitation is less harmful to surrounding tissuecompared to inertial cavitation, it also contributes to enhancedtumor perfusion. Hence, an optimal strategy could involve in-ducing inertial cavitation only within the tumor region for drugrelease and mapping, while employing stable cavitation out-side the tumor to enhance perfusion. This study aims to inves-tigate stable cavitation mediated by MNPs for the first time,while examining their overall cavitation behavior.
APA:
Huber, C., Hageroth, L., Meyer, C., Ermert, H., Ullmann, I., Vossiek, M., & Lyer, S. (2024). Ultrasound-Induced Stable and Inertial Cavitation of Magnetic Nanoparticles for Drug Delivery Applications. Current Directions in Biomedical Engineering, 10, 328-331. https://doi.org/10.1515/cdbme-2024-2080
MLA:
Huber, Christian, et al. "Ultrasound-Induced Stable and Inertial Cavitation of Magnetic Nanoparticles for Drug Delivery Applications." Current Directions in Biomedical Engineering 10 (2024): 328-331.
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