Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review
Piazza C, Montenegro C, Tomasoni M, Leivo I, Stenman G, Agaimy A, Simpson RH, Zidar N, Ferlito A (2025)
Publication Type: Journal article, Review article
Publication year: 2025
Journal
Article Number: b2700
DOI: 10.1007/s40487-024-00323-1
Abstract
Introduction: Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate treatment modalities and survival outcomes in patients affected by these rarer CS subtypes. Methods: Papers published from January 1, 2000, to August 25, 2024, describing cases of laryngeal G3, DD, and MY CS were included. Results: A total of 38 patients (15 G3, 13 DD, and 10 MY) were selected. Cricoid cartilage was the most common site of origin. Total laryngectomy (TL) was often performed. Primary conservative approaches in 42.8% of patients were followed by loco-regional recurrence. Conclusions: Aggressive subtypes of CS require a radical approach because of the higher rate of loco-regional and distant recurrences compared to low-grade CS. TL with radical intent is the most common treatment, and adjuvant therapy should be considered after careful multidisciplinary discussion.
Authors with CRIS profile
Involved external institutions
International Head and Neck Scientific Group
Germany (DE)
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Italy (IT)
Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS)
Finland (FI)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
University of Calgary
Canada (CA)
University of Ljubljana (UL) / Univerza v Ljubljani
Slovenia (SI)
Germany (DE)
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Italy (IT)
Turku University Hospital / Turun yliopistollinen keskussairaala (TYKS)
Finland (FI)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
University of Calgary
Canada (CA)
University of Ljubljana (UL) / Univerza v Ljubljani
Slovenia (SI)
How to cite
APA:
Piazza, C., Montenegro, C., Tomasoni, M., Leivo, I., Stenman, G., Agaimy, A.,... Ferlito, A. (2025). Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review. Oncology and Therapy. https://doi.org/10.1007/s40487-024-00323-1
MLA:
Piazza, Cesare, et al. "Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review." Oncology and Therapy (2025).
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