Ferroptosis in health and disease.

Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FC, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M (2024)

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Book Volume: 75

DOI: 10.1016/j.redox.2024.103211

Abstract

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to rupture of the plasma membrane. Ferroptosis is unique in that it is essentially a spontaneous, uncatalyzed chemical process based on perturbed iron and redox homeostasis contributing to the cell death process, but that it is nonetheless modulated by many metabolic nodes that impinge on the cells' susceptibility to ferroptosis. Among the various nodes affecting ferroptosis sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets for the treatment of numerous currently incurable diseases. Herein, the current members of a Germany-wide research consortium focusing on ferroptosis research, as well as key external experts in ferroptosis who have made seminal contributions to this rapidly growing and exciting field of research, have gathered to provide a comprehensive, state-of-the-art review on ferroptosis. Specific topics include: basic mechanisms, in vivo relevance, specialized methodologies, chemical and pharmacological tools, and the potential contribution of ferroptosis to disease etiopathology and progression. We hope that this article will not only provide established scientists and newcomers to the field with an overview of the multiple facets of ferroptosis, but also encourage additional efforts to characterize further molecular pathways modulating ferroptosis, with the ultimate goal to develop novel pharmacotherapies to tackle the various diseases associated with - or caused by - ferroptosis.

Involved external institutions

Universitätsklinikum Carl Gustav Carus Dresden Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Columbia University United States (USA) (US) Columbia University Irving Medical Center (CUIMC) United States (USA) (US) Goethe-Universität Frankfurt am Main Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universität zu Köln Germany (DE) University of Antwerp / Universiteit Antwerpen Belgium (BE) Memorial Sloan Kettering Cancer Center United States (USA) (US) University of Pittsburgh United States (USA) (US) Klinikum der Universität München Germany (DE) Rockefeller University United States (USA) (US) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Germany (DE) Weizmann Institute of Science Israel (IL) National University of Mar del Plata / Universidad Nacional de Mar del Plata (UNMdP) Argentina (AR) Nankai University (NKU) / 南开大学 China (CN) H. Lee Moffitt Cancer Center & Research Institute United States (USA) (US) Stanford University United States (USA) (US) DKFZ-ZMBH-Allianz Germany (DE) Zhejiang University / Chekiang University / 浙江大学 China (CN) Tohoku University Japan (JP) Heinrich-Heine-Universität Düsseldorf Germany (DE) Institut Curie France (FR) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) University of California, Berkeley United States (USA) (US) New York University (NYU) United States (USA) (US) University of Ottawa Canada (CA) Technische Universität München (TUM) Germany (DE) Seoul National University (SNU) / 서울대학교 Korea, Republic of (KR) Université de Lausanne (UNIL) Switzerland (CH) Deutsches Zentrum für Lungenforschung e.V. (DZL) Germany (DE) West China Medical Center of Sichuan University / 四川大学华西医学中心 China (CN) Nagoya University / 名古屋大学 Japan (JP) Universitätsklinikum Würzburg Germany (DE) Universitätsklinikum Bonn Germany (DE) Universiteit Gent (UGent) / Ghent University Belgium (BE) The University of Melbourne Australia (AU)

How to cite

APA:

Berndt, C., Alborzinia, H., Amen, V.S., Ayton, S., Barayeu, U., Bartelt, A.,... Conrad, M. (2024). Ferroptosis in health and disease. Redox Biology, 75. https://doi.org/10.1016/j.redox.2024.103211

MLA:

Berndt, Carsten, et al. "Ferroptosis in health and disease." Redox Biology 75 (2024).

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