Pfister H (2024)
Publication Type: Authored book
Publication year: 2024
Publisher: CRC Press
ISBN: 9781040293706
Warts on the skin and the genitalia have been well-known papillomatous tumors since ancient times. Their viral origin was postulated in 1907 by Ciuffo, 1 who was able to induce common warts in volunteers by injecting them with cell-free filtrates of wart extracts. Successful transmission experiments were also carried out later on with cell-free extracts of condylomata acuminata (genital warts) and laryngeal papillomas. 2 Virus particles were demonstrated by the electron microscope in the upper epithelial layers of these lesions. 3–5 Kreider and colleagues recently infected cervical mucosa biopsies in vitro with virus-positive genital wart extracts and obtained condylomatous proliferations after grafting the tissue beneath the renal capsule of an athymic mouse, 6 which finally proved the oncogenic activity of the virus under controlled experimental conditions.
APA:
Pfister, H. (2024). GENERAL INTRODUCTION TO PAPILLOMA VIRUSES. CRC Press.
MLA:
Pfister, Herbert. GENERAL INTRODUCTION TO PAPILLOMA VIRUSES. CRC Press, 2024.
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